Tractography based on diffusion tensor imaging (DTI) data has been used as a tool by a
large number of recent studies to investigate structural connectome. Despite its great
success in offering unique 3D neuroanatomy information, DTI is an indirect observation with
limited resolution and accuracy and its reliability is still unclear. Thus, it is essential to
answer this fundamental question: how reliable is DTI tractography in constructing large-
scale connectome? To answer this question, we employed neuron tracing data of 1772 …